Joining efforts for the non-invasive evaluation in pulmonary hypertension: TAPSE/sPAP ratio

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Pulmonary hypertension remains an important challenge given its still elevated mortality rate and complex clinical management, especially when it comes to risk stratification imaging evaluation. In this respect, TAPSE/sPAP ratio obtained by echo is a surrogate PA-RV coupling has been suggested as complementary approach PH diagnosis stratification. However, cut-offs for are yet be clarified recent guidelines refer cut-off 0,55, whilst other papers point that lower 0,35 could better estimate prognosis. Purpose To analyse impact in our population define ideal best correlate with invasive hemodynamics Methods Single center retrospective study patients precapillary pulmonary who underwent right heart catheterization (RHC) echocardiography within time frame 2 months. Clinical, laboratorial, cath data were collected statistical analysis was performed using Chi-square test, Mann-Whitney well ROC curve Kaplan-Meier survival. Results We analysed 79 (66% female, mean age 58,06 +- 15,3) pre-capillary – 53% had group 1 47% 4 followed during period 3,6 ±2,8years. Most under specific therapy (93%), mostly PDE5 inhibitors endothelin receptor antagonists. According guidelines, derived 0,55 used correlated hemodynamic parameters, namely mPAP (p = 0,005), RAP 0,007), cardiac output 0,007) index 0,045) vascular resistance 0,01). ratio<0,55 not predict prognosis failed show correlation COMPERA score follow-up 0,69), events 0,31), progression triple or death 0,45). Pts alternatively divided into tertiles ratios <0,29, 0,30–0,58 >0,59. These showed positive on 0,05) death. clear separation the three groups these values. revealed 0,39 sensitivity specificity (figure 2). Conclusion good parameters pts hypertension. Notwithstanding, survival